Ureadepsipeptides as ClpP Activators
نویسندگان
چکیده
منابع مشابه
Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease.
ClpP is a cylindrical serine protease whose ability to degrade proteins is regulated by the unfoldase ATP-dependent chaperones. ClpP on its own can only degrade small peptides. Here, we used ClpP as a target in a high-throughput screen for compounds, which activate the protease and allow it to degrade larger proteins, hence, abolishing the specificity arising from the ATP-dependent chaperones. ...
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ژورنال
عنوان ژورنال: ACS Infectious Diseases
سال: 2019
ISSN: 2373-8227,2373-8227
DOI: 10.1021/acsinfecdis.9b00245